“The server was acting as a gateway or proxy and did not receive a timely response from the upstream server.“ — wikipedia
“The server, while acting as a gateway or proxy, did not receive a timely response from the upstream server specified by the URI (e.g. HTTP, FTP, LDAP) or some other auxiliary server (e.g. DNS) it needed to access in attempting to complete the request.
Note: Note to implementors: some deployed proxies are known to return 400 or 500 when DNS lookups time out.“ — ietf